This project proposes the creation of a smart emergency response system based on a Digital Twin (DT) of the “0+Infinito” pavilion — a 17,200 m² sustainable smart building at the University of Buenos Aires, which hosts more than 5,000 users daily. The system will simulate critical emergency scenarios, such as fires or gas leaks, and provide dynamic evacuation route optimization based on real-time conditions. By integrating Unreal Engine for 3D visualization and synthetic data generation with PowerDEVS, a scientific simulation toolkit, the DT will be continuously updated using sensor inputs and mobile robot data, reflecting the actual occupancy, layout, and environmental status of the building.